COLUMBUS, Ohio — Draymond Green scored 16 points with 13 rebounds and set up Keith Appling's crucial 3-pointer with 1:34 left, giving top-seeded Michigan State a 65-61 win over Saint Louis on Sunday and sending the Spartans to the round of 16 in the NCAA tournament.

Michigan State will play No. 4 seed Louisville in the West Regional semifinals Thursday in Phoenix.

Appling added 19 points for the Spartans (29-7), who had to scrap their way past the ninth-seeded Billikens (26-8). Saint Louis controlled the tempo but never got a complete handle on Green, Michigan State's superb senior. He added six assists and even helped mop up sweat off the floor in the final minute.

Kwamain Mitchell scored 13 and Brian Conklin 11 for Saint Louis, back in the tournament for the first time since 2000.

No. 7 FLORIDA 84, No. 15 NORFOLK STATE 50

OMAHA, Neb. — Kenny Boynton scored 20 points and Florida routed Norfolk State to reach the regional semifinals of the NCAA tournament for the second straight year.

Norfolk State shook up the West Regional when it upset No. 2 seed Missouri 86-84 on Friday and was trying to become the first 15 seed to reach the round of 16.

Florida put a quick end to that idea, making five 3-pointers during a 25-0 run that made it 29-6 midway through the first half.

The Gators (25-10) made it to the regional semifinals for the sixth time in 12 NCAA tournament appearances under coach Billy Donovan. They will play No. 3 seed Marquette on Thursday in Phoenix after their second straight runaway win.

Florida was 4 for 23 from beyond the arc in its tournament opener, but still managed to beat Virginia 71-45. It rediscovered its shooting touch early against Norfolk State (26-10), making five of its first eight 3-point attempts and 10 of 28 for the game.

MIDWEST REGIONAL

No. 1 NORTH CAROLINA 87, No. 8 CREIGHTON 73

GREENSBORO, N.C. — John Henson proved he's healthy enough to help North Carolina's latest push for the Final Four. It remains to be seen if Kendall Marshall will be able to help the Tar Heels.

Henson had 13 points, 10 rebounds and four blocks in his return from a wrist injury, but Marshall broke a bone in his right wrist during the second half of North Carolina's third-round victory over Creighton.

Coach Roy Williams confirmed the injury after the game, and said he would talk to Marshall and his parents about his status Sunday night. The point guard still finished with 18 points and 11 assists.

North Carolina got off to a fast start and built a 15-point lead in the first half, then kept control and pushed the margin to 19 after the break on the way to its second straight double-digit victory in the Midwest Regional. The top-seeded Tar Heels (31-5) reached the round of 16 for a record 25th time.

Doug McDermott scored 20 points for the Bluejays (29-6), who shot 41 percent and couldn't keep up with the hot-shooting Tar Heels.

No. 11 NORTH CAROLINA STATE 66,

No. 3 GEORGETOWN 63

Lorenzo Brown hit three free throws in the final 10.6 seconds and North Carolina State conjured up its glorious tradition by upsetting Georgetown.

The Wolfpack (24-12) advance to play the Purdue-Kansas winner on Friday in St. Louis.

A lowly 11th seed coming in, they had to survive a furious comeback by the Hoyas (24-9) and only were assured of the win when Jason Clark's hurried 3-point attempt from the right wing was off the mark at the buzzer.

C.J. Williams, Scott Wood and C.J. Leslie each had 14 points, and Brown added 12 for the Wolfpack, who earned their first trip to the round of 16 since 2005.

Hollis Thompson led the Hoyas with 23 points.