KANSAS CITY— Indians right-hander Carlos Carrasco threw seven innings and the offense hammered Royals starter Danny Duffy early en route to a 10-3 victory on Wednesday night at Kauffman Stadium.

Carrasco, staked at one point to a 6-0 lead, put it on cruise control, allowing five hits and three runs while striking out six and keeping the Royals at a safe distance.

“He’s tough because he uses his changeup well,” Royals first baseman Eric Hosmer said. “You may get one pitch during an at-bat. But he has that 97-mph fastball and it makes it tough.”

“I thought he did really well,” Indians manager Terry Francona said of Carrasco. “We got on the scoreboard early, which is a good way to win. And he pitched really effectively against a lineup that feels pretty good about themselves.”

The Indians chased Duffy in the second when five straight hitters reached safely. Lonnie Chisenhall, former Royal Brett Hayes and Jason Kipnis all delivered RBI hits, the last of which sent Duffy to the showers.

Duffy’s start was the shortest non-injury outing of his career. He was charged with four runs and six hits in one-plus innings.

“He just looked out of sorts to me,” Royals manager Ned Yost said. “ ... and it didn’t look like he was going to find it.”

Cleveland’s Brandon Moss homered and doubled and drove in three runs.