Wegovy, Ozempic, and Rybelsus are three popular pharmaceuticals you likely know by name due to their catchy commercials, celebrity endorsements, and social media presence. While 50% of Americans are currently trying to lose weight, interest in these drugs is at an all-time high. All of these medications are known for their weight loss effects, and they are FDA-approved. They sound too good to be true. Are they?
Wegovy is approved for weight loss while Ozempic and Rybelsus are approved for diabetes, but sometimes they are prescribed “off-label” to treat obesity. While these medications have proven to be very successful in managing diabetes and reducing obesity, some factors should be taken into consideration before you ask your doctor about them.
There are common side effects, some of which affect the gastrointestinal system. In fact, about 50% of people report regular nausea and diarrhea, but more serious outcomes have been seen in people taking the drugs long-term. These issues span from gastroparesis, bowel obstruction, and pancreatitis, to muscle loss. Since the medications are relatively new to the general population, there isn’t much information on how the drugs affect biological function years down the road. The medications are usually a lifelong commitment as studies show that people who discontinue them gain most weight back within one year. So, if these effects are evident now, what will future consequences be?
Although it is hard to know if these drugs will be considered safe in the long run, the science behind the medication is quite interesting. It could also be beneficial in finding safe weight loss methods.
Wegovy, Ozempic, and Rybelsus are semiglutides that mimic the GLP-1 hormone which prompts the body to produce insulin. This reduces blood sugar. In higher dosages, the drugs suppress appetite and slow stomach emptying. These effects prove to help people manage diabetes and lose weight. Since the drugs mimic a naturally occurring hormone, supporting the body’s production of GLP-1 can result in safe weight loss and blood sugar control.
Natural methods of supporting GLP-1 include the intake of foods that boost the secretion of the hormone. Studies report that unsaturated, omega-3 fatty acids, protein, and high-fiber foods tend to result in the highest levels of GLP-1 secretion.
Sources of unsaturated fats include avocados, almonds, walnuts, pistachios, and other nuts. Seafood like salmon, mackerel, and cod are other great sources of omega-3 fatty acids. Quality oils like olive oil and flaxseed oil are also great choices to increase your healthy fat intake.
Eating enough protein per day can also provide feelings of fullness through GLP-1 secretion. The Academy of Nutrition and Dietetics recommends that the average adult consumes at least 0.35 grams of protein per pound of body weight. Several lean proteins include chicken breast, fish, plain Greek yogurt, cottage cheese, beans, and lentils.
High-fiber foods also induce satiety through GLP-1. Specifically, soluble fiber in foods such as barley, oats, peas, beans, lentils, and apples are fermentable. This means they digest slowly, support the gut microbiome, and produce GLP-1 hours after eating.
Although there are circumstances when a prescription is necessary, using food as medicine is a promising strategy for weight loss. Creating a lifestyle with a diet high in unsaturated fat, lean protein, and fiber has the potential to impact weight, diabetes management, and quality of life without dangerous side effects.
Karissa Winkel is the family and community wellness agent with K-State Research and Extension – Cottonwood District. Contact her at 620-793-1910 or krwinkel@ksu.edu.
